[Population genomic researches of Escherichia coli].
Zhonghua Yu Fang Yi Xue Za Zhi
; 50(6): 554-8, 2016 Jun.
Article
en Zh
| MEDLINE
| ID: mdl-27256740
ABSTRACT
Population genomics, an interdiscipline of genomics and population genetics, is booming in recent years with the rapid growth number of deciphered genomes and revolutionizes the understanding of bacterial population diversity and evolution dynamics. It also largely improves the prevention and control of infectious disease through providing more accurate genotyping and source-tracing results and more comprehensive characteristics of emerging pathogens. In this review, taking one of the best characterized bacteria, Escherichia coli, as model, we reviewed the phylogenetic relationship across its five major populations (designated A, B1, B2, D and E); and summarized researches on molecular mutation rate, selection signals, and patterns of adaptive evolution. We also described the application of population genomics in responding against large-scale outbreaks of E. coli O157H7 and E. coli O104H4. These results indicated that, although being a novel discipline, population genomics has played an important role in deciphering bacterial population structures, exploring evolutionary patterns and combating emerging infectious diseases.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Genoma Bacteriano
/
Escherichia coli O157
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Genómica
/
Metagenómica
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
Zh
Revista:
Zhonghua Yu Fang Yi Xue Za Zhi
Año:
2016
Tipo del documento:
Article
País de afiliación:
China