Belatacept Conversion in an HIV-Positive Kidney Transplant Recipient With Prolonged Delayed Graft Function.
Am J Transplant
; 16(11): 3278-3281, 2016 11.
Article
en En
| MEDLINE
| ID: mdl-27328903
ABSTRACT
We report an HIV-positive renal transplant recipient with delayed graft function who was converted from tacrolimus to belatacept in an attempt to improve renal function. The patient had kidney biopsies at 4 and 8 weeks posttransplant that revealed acute tubular necrosis and mild fibrosis. After 14 weeks of delayed function, belatacept was initiated and tacrolimus was weaned off. Shortly after discontinuing tacrolimus, renal function began to improve. The patient was able to discontinue dialysis 21 weeks posttransplant. HIV viral load was undetectable at last follow-up. To our knowledge, this is the first report of belatacept use in a patient with HIV.
Palabras clave
clinical research/practice; delayed graft function (DGF); fusion proteins and monoclonal antibodies: belatacept; immunosuppressant; immunosuppression/immune modulation; immunosuppressive regimens; infection and infectious agents; infectious disease; kidney transplantation/nephrology; maintenance; viral: human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS)
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Infecciones por VIH
/
Trasplante de Riñón
/
Funcionamiento Retardado del Injerto
/
Abatacept
/
Rechazo de Injerto
/
Fallo Renal Crónico
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am J Transplant
Asunto de la revista:
TRANSPLANTE
Año:
2016
Tipo del documento:
Article