Stereochemical Assignment and Biological Evaluation of BE-14106 Unveils the Importance of One Acetate Unit for the Antifungal Activity of Polyene Macrolactams.

Fujita, Kohei; Sugiyama, Ryosuke; Nishimura, Shinichi; Ishikawa, Naoki; Arai, Midori A; Ishibashi, Masami; Kakeya, Hideaki

Fujita, Kohei; Sugiyama, Ryosuke; Nishimura, Shinichi; Ishikawa, Naoki; Arai, Midori A; Ishibashi, Masami; Kakeya, Hideaki.

Afiliación

Fujita K; Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University , Sakyo-ku, Kyoto 606-8501, Japan.
Sugiyama R; Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University , Sakyo-ku, Kyoto 606-8501, Japan.
Nishimura S; Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University , Sakyo-ku, Kyoto 606-8501, Japan.
Ishikawa N; Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Arai MA; Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Ishibashi M; Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
Kakeya H; Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University , Sakyo-ku, Kyoto 606-8501, Japan.

J Nat Prod ; 79(7): 1877-80, 2016 07 22.

Article en En | MEDLINE | ID: mdl-27331864

Asunto(s)

Actinobacteria/química; Antibacterianos/aislamiento & purificación; Antifúngicos/aislamiento & purificación; Antifúngicos/farmacología; Lactamas/farmacología; Antibacterianos/química; Antibacterianos/farmacología; Antifúngicos/química; Lactamas/química; Lactamas Macrocíclicas/química; Lactamas Macrocíclicas/farmacología; Biología Marina; Estructura Molecular; Schizosaccharomyces/efectos de los fármacos; Relación Estructura-Actividad

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Actinobacteria / Lactamas / Antibacterianos / Antifúngicos Idioma: En Revista: J Nat Prod Año: 2016 Tipo del documento: Article País de afiliación: Japón

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