A Fluorescence-Based High-Throughput Coupled Enzymatic Assay for Quantitation of Isoaspartate in Proteins and Peptides.

Puri, Aastha; Quan, Yong; Narang, Ajit S; Adams, Monica; Gandhi, Rajesh; Nashine, Vishal C

Puri, Aastha; Quan, Yong; Narang, Ajit S; Adams, Monica; Gandhi, Rajesh; Nashine, Vishal C.

Afiliación

Puri A; Drug Product Science & Technology, Bristol-Myers Squibb, Co., 1 Squibb Drive, New Brunswick, New Jersey, 08901, USA.
Quan Y; Drug Product Science & Technology, Bristol-Myers Squibb, Co., 1 Squibb Drive, New Brunswick, New Jersey, 08901, USA.
Narang AS; Drug Product Science & Technology, Bristol-Myers Squibb, Co., 1 Squibb Drive, New Brunswick, New Jersey, 08901, USA.
Adams M; Drug Product Science & Technology, Bristol-Myers Squibb, Co., 1 Squibb Drive, New Brunswick, New Jersey, 08901, USA.
Gandhi R; Drug Product Science & Technology, Bristol-Myers Squibb, Co., 1 Squibb Drive, New Brunswick, New Jersey, 08901, USA.
Nashine VC; Drug Product Science & Technology, Bristol-Myers Squibb, Co., 1 Squibb Drive, New Brunswick, New Jersey, 08901, USA. vishal.nashine@bms.com.

AAPS PharmSciTech ; 18(3): 803-808, 2017 Apr.

Article en En | MEDLINE | ID: mdl-27342117

Asunto(s)

Ácido Isoaspártico/química; Péptidos/química; Proteínas/química; Asparagina/química; Ácido Aspártico/química; Pruebas de Enzimas/métodos; Fluorescencia; Isomerismo

Palabras clave

deamidation; fluorescence; high-throughput; isoaspartate; protein; stability

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Péptidos / Proteínas / Ácido Isoaspártico Idioma: En Revista: AAPS PharmSciTech Asunto de la revista: FARMACOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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