Your browser doesn't support javascript.
loading
Aleukemic Leukemia Cutis Presenting as a Sole Sign of Relapsed Paediatric Acute Lymphoblastic Leukemia.
Joshi, Kshitij; Panchal, Harsha; Parikh, Sonia; Modi, Gaurang; Talele, Avinash; Anand, Asha; Uparkar, Urmila; Joshi, Nitin; Khatawani, Itesh.
Afiliación
  • Joshi K; Department of Medical and Pediatric Oncology, Gujarat Cancer Research Centre (GCRI), Ahmadabad, Gujarat India ; 1, Akshar, Parth Housing Society, Sai Nagar, Near R.T.O. Corner, Dindori Road, Nashik, Maharashtra 422004 India.
  • Panchal H; Department of Medical and Pediatric Oncology, Gujarat Cancer Research Centre (GCRI), Ahmadabad, Gujarat India.
  • Parikh S; Department of Medical and Pediatric Oncology, Gujarat Cancer Research Centre (GCRI), Ahmadabad, Gujarat India.
  • Modi G; Department of Medical and Pediatric Oncology, Gujarat Cancer Research Centre (GCRI), Ahmadabad, Gujarat India.
  • Talele A; Department of Medical and Pediatric Oncology, Gujarat Cancer Research Centre (GCRI), Ahmadabad, Gujarat India.
  • Anand A; Department of Medical and Pediatric Oncology, Gujarat Cancer Research Centre (GCRI), Ahmadabad, Gujarat India.
  • Uparkar U; Department of Medical and Pediatric Oncology, Gujarat Cancer Research Centre (GCRI), Ahmadabad, Gujarat India.
  • Joshi N; Department of Medical and Pediatric Oncology, Gujarat Cancer Research Centre (GCRI), Ahmadabad, Gujarat India.
  • Khatawani I; Department of Medical and Pediatric Oncology, Gujarat Cancer Research Centre (GCRI), Ahmadabad, Gujarat India.
Indian J Hematol Blood Transfus ; 32(Suppl 1): 46-9, 2016 Jun.
Article en En | MEDLINE | ID: mdl-27408353
ABSTRACT
The author describes paediatric case of relapsed acute lymphoblastic leukaemia (ALL) presented as aleukemic leukaemia cutis (ALC). A 2 year old child was admitted in tertiary oncology centre. He suffered from pre B cell ALL with absent Philadelphia chromosome. This patient received multiagent induction chemotherapy as per Berlin-Frankfurt-Munster (BFM) protocol for ALL. He achieved remission after 28 days of treatment. Subsequently he presented with multiple skin lesions in the form of multiple small erythematous violaceous macules, papules, plaques and nodules on face, chest and back regions. Histopathological examination of biopsy of skin revealed diffuse infiltration of tumor cells with prominent nucleoli, scant eosinophilic cytoplasm and numerous mitotic figures consistent with LC. Immunohistochemistry was positive for CD 10, CD 19, CD 22, CD 24, CD 79-a and TdT while negative for surface immunoglobulin. At the time of presentation his peripheral blood smear and bone marrow examination was negative for malignant cells. Sanctuary sites including central nervous system and testicles were not involved. So patient was diagnosed as ALC. He was managed as per BFM relapse protocol for ALL. Skin lesions disappeared completely after 2 weeks of treatment. Unfortunately patient developed bone marrow and testicular relapse after 2 months. He was given testicular radiotherapy and systemic chemotherapy for relapsed ALL. But his marrow was showing persistent activity and he expired after 4 months.
Palabras clave

Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: Indian J Hematol Blood Transfus Año: 2016 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: Indian J Hematol Blood Transfus Año: 2016 Tipo del documento: Article