Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis.
Cell Metab
; 24(1): 151-7, 2016 07 12.
Article
en En
| MEDLINE
| ID: mdl-27411015
ABSTRACT
Beneficial effects of dietary fiber on glucose and energy homeostasis have long been described, focusing mostly on the production of short-chain fatty acids by the gut commensal bacteria. However, bacterial fermentation of dietary fiber also produces large amounts of succinate and, to date, no study has focused on the role of succinate on host metabolism. Here, we fed mice a fiber-rich diet and found that succinate was the most abundant carboxylic acid in the cecum. Dietary succinate was identified as a substrate for intestinal gluconeogenesis (IGN), a process that improves glucose homeostasis. Accordingly, dietary succinate improved glucose and insulin tolerance in wild-type mice, but those effects were absent in mice deficient in IGN. Conventional mice colonized with the succinate producer Prevotella copri exhibited metabolic benefits, which could be related to succinate-activated IGN. Thus, microbiota-produced succinate is a previously unsuspected bacterial metabolite improving glycemic control through activation of IGN.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Ácido Succínico
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Microbiota
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Gluconeogénesis
/
Glucosa
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Homeostasis
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Mucosa Intestinal
Límite:
Animals
Idioma:
En
Revista:
Cell Metab
Asunto de la revista:
METABOLISMO
Año:
2016
Tipo del documento:
Article
País de afiliación:
Suecia