Effect of Partially Fluorinated N-Alkyl-Substituted Piperidine-2-carboxamides on Pharmacologically Relevant Properties.

Vorberg, Raffael; Trapp, Nils; Zimmerli, Daniel; Wagner, Björn; Fischer, Holger; Kratochwil, Nicole A; Kansy, Manfred; Carreira, Erick M; Müller, Klaus

Vorberg, Raffael; Trapp, Nils; Zimmerli, Daniel; Wagner, Björn; Fischer, Holger; Kratochwil, Nicole A; Kansy, Manfred; Carreira, Erick M; Müller, Klaus.

Afiliación

Vorberg R; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, HCI, 8093, Zürich, Switzerland.
Trapp N; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, HCI, 8093, Zürich, Switzerland.
Zimmerli D; F.âHoffmann-LaâRoche AG, Pharmaceutical Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Wagner B; F.âHoffmann-LaâRoche AG, Pharmaceutical Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Fischer H; F.âHoffmann-LaâRoche AG, Pharmaceutical Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Kratochwil NA; F.âHoffmann-LaâRoche AG, Pharmaceutical Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Kansy M; F.âHoffmann-LaâRoche AG, Pharmaceutical Research & Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland.
Carreira EM; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, HCI, 8093, Zürich, Switzerland. erickm.carreira@org.chem.ethz.ch.
Müller K; Laboratorium für Organische Chemie, ETH Zürich, Vladimir-Prelog-Weg 3, HCI, 8093, Zürich, Switzerland. klaus.mueller@org.chem.ethz.ch.

ChemMedChem ; 11(19): 2216-2239, 2016 10 06.

Article en En | MEDLINE | ID: mdl-27629993

Asunto(s)

Piperidinas/química; Piperidinas/farmacología; Relación Dosis-Respuesta a Droga; Halogenación; Humanos; Interacciones Hidrofóbicas e Hidrofílicas; Microsomas Hepáticos/química; Microsomas Hepáticos/metabolismo; Estructura Molecular; Piperidinas/síntesis química; Piperidinas/metabolismo; Relación Estructura-Actividad; Temperatura

Palabras clave

fluorine; levobupivacaine; partial fluorination patterns; pharmacological properties; ropivacaine

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Piperidinas Límite: Humans Idioma: En Revista: ChemMedChem Asunto de la revista: FARMACOLOGIA / QUIMICA Año: 2016 Tipo del documento: Article País de afiliación: Suiza

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