Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A.
Transl Psychiatry
; 6(9): e901, 2016 Sep 27.
Article
en En
| MEDLINE
| ID: mdl-27676442
ABSTRACT
Duchenne muscular dystrophy is caused by mutations in the DYSTROPHIN gene. Although primarily associated with muscle wasting, a significant portion of patients (approximately 25%) are also diagnosed with autism spectrum disorder. We describe social behavioral deficits in dystrophin-deficient mice and present evidence of cerebellar deficits in cGMP production. We demonstrate therapeutic potential for selective inhibitors of the cGMP-specific PDE5A and PDE9A enzymes to restore social behaviors in dystrophin-deficient mice.
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Base de datos:
MEDLINE
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En
Revista:
Transl Psychiatry
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos