Increased striatal VMAT2 binding in mice after chronic administration of methcathinone and manganese.
Brain Res
; 1652: 97-102, 2016 12 01.
Article
en En
| MEDLINE
| ID: mdl-27693414
ABSTRACT
Intravenous use of a psychostimulant drug containing methcathinone (ephedrone) and manganese causes an irreversible extrapyramidal syndrome in drug abusers. We aimed to reproduce the syndrome in mice to evaluate dopaminergic damage. C57/B6 mice were intraperitoneally injected once a day with the study drug or saline for a period of 27 weeks. Motor activity was recorded in an automated motility-box. After 13 and 27 weeks of treatment, ex vivo digital autoradiography was performed using [11C]dihydrotetrabenazine ([11C]DTBZ). After 27 weeks of treatment [11C]DTBZ autoradiography demonstrated a significant increase in the striatum-to-cerebellum binding ratio compared with saline treated controls. At the same time point, there was no evident change in motor activity. Increased [11C]DTBZ binding may indicate vesicular monoamine transporter type 2 (VMAT2) function is altered. The lack of extrapyramidal symptoms in animals could be attributed to low dosing regimen or high metabolic rate.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Propiofenonas
/
Psicotrópicos
/
Trastornos Relacionados con Sustancias
/
Cuerpo Estriado
/
Proteínas de Transporte Vesicular de Monoaminas
/
Manganeso
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Brain Res
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estonia