Cross-sectional study on allergic sensitization of Austrian adolescents using molecule-based IgE profiling.
Allergy
; 72(5): 754-763, 2017 May.
Article
en En
| MEDLINE
| ID: mdl-27753449
ABSTRACT
BACKGROUND:
Allergen-specific IgE antibodies are a hallmark of type I allergy. The aim of this cross-sectional study was to analyze the sensitization profiles of an Austrian adolescent population utilizing molecule-based IgE diagnosis.METHODS:
Serum samples of 501 nonselected pupils from Salzburg, Austria, were tested in ImmunoCAP ISAC® for IgE reactivity to 112 single allergens. Sensitization profiles were assessed and statistically coordinated with reported allergies.RESULTS:
In the population aged 12-21 years, 53.5% showed IgE reactivity to at least one allergen tested. The highest prevalence was found for Phl p 1 from grass pollen (26.5%), group 2 mite allergens (18.2%), Bet v 1 from birch pollen (16.3%) and Fel d 1 from cat (14.4%). The majority of participants showed a complex sensitization profile and reacted on average to 9 allergens. Pollen sensitization was highly prevalent (41.7%) and mainly driven by group I grass and PR-10 allergens of the Betulaceae family, while Pla l 1 represented the most relevant weed. Diagnosed and self-reported allergies were noted in 21.9% and 45.5% of participants, respectively, and correlated well with in vitro results. Among atopic individuals, 71.4% reported to suffer from at least one allergy; concordance was found for grass and cat sensitization, while venom- and weed pollen-positive individuals were frequently asymptomatic.CONCLUSIONS:
More than half of the tested adolescent population had already established an atopic status presenting a complex IgE reactivity profile dominated by pollen sensitization. Detailed molecule-based analysis allows determining relevant biomarkers and monitoring of the atopic status in populations.Palabras clave
Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Inmunoglobulina E
/
Alérgenos
/
Hipersensibilidad
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Adolescent
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Adult
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Child
/
Female
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Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Revista:
Allergy
Año:
2017
Tipo del documento:
Article
País de afiliación:
Austria