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In Vitro Activities of Novel Azole Compounds ATTAF-1 and ATTAF-2 against Fluconazole-Susceptible and -Resistant Isolates of Candida Species.
Fakhim, Hamed; Emami, Saeed; Vaezi, Afsane; Hashemi, Seyedeh Mahdieh; Faeli, Leila; Diba, Kambiz; Dannaoui, Eric; Badali, Hamid.
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  • Fakhim H; Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
  • Emami S; Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
  • Vaezi A; Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
  • Hashemi SM; Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
  • Faeli L; Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
  • Diba K; Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
  • Dannaoui E; Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
  • Badali H; Department of Medical Mycology and Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Antimicrob Agents Chemother ; 61(1)2017 01.
Article en En | MEDLINE | ID: mdl-27795371
ABSTRACT
The in vitro activities of two novel azole compounds (aryl-1,2,4-triazol-3-ylthio analogues of fluconazole [ATTAFs]) and five comparator antifungal agents against 52 clinical Candida isolates from 5 different species were determined. The novel azole compounds had the lowest geometric mean MICs, followed by fluconazole. Moreover, combinations of these compounds with fluconazole exhibited synergistic effects against fluconazole-susceptible (22 of 23 isolates), fluconazole-susceptible dose-dependent (10 of 13 isolates), and fluconazole-resistant (1 of 16 isolates) Candida isolates.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Azoles / Fluconazol / Antifúngicos Idioma: En Revista: Antimicrob Agents Chemother Año: 2017 Tipo del documento: Article País de afiliación: Irán
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Azoles / Fluconazol / Antifúngicos Idioma: En Revista: Antimicrob Agents Chemother Año: 2017 Tipo del documento: Article País de afiliación: Irán