[Whole-genome sequencing in German clinical practice : Economic impacts of its use in selected areas of application]. / Ganzgenomsequenzierung in der deutschen Versorgung : Ökonomische Auswirkungen eines Einsatzes in ausgewählten Anwendungsgebieten.
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
; 60(2): 143-150, 2017 Feb.
Article
en De
| MEDLINE
| ID: mdl-27999872
ABSTRACT
BACKGROUND:
The diagnostic use of whole-genome sequencing (WGS) is a growing issue in medical care. Due to limited resources in public health service, budget-impact analyses are necessary prior to implementation.OBJECTIVE:
A budget-impact analysis for WGS of all newborns and diagnostic investigation of tumor patients in different oncologic indications were evaluated.METHODS:
A cost analysis of WGS based on a quality-assured process chart for WGS at the German Cancer Research Center (DKFZ), Heidelberg, constitutes the basis for this evaluation. Data from the National Association of Statutory Health Insurance Funds and the Robert-Koch-Institute, Berlin, were used for calculations of specific clinical applications. RESULTS ANDDISCUSSION:
WGS in newborn screening leads to costs of 2.85 bn and to an increase of total expenditure by 1.41%. Sequencing of all tumor patients would cost approximately 0.84 bn, which corresponds to 0.42% of total expenditures. In all scenarios, the sole consideration of procedure costs results in increasing costs. However, in cost discussions potential savings (reduction of disease-related follow-up-costs, improved cost-effectiveness of medical measures etc.) should be considered. Such considerations are the subject of economic indication-specific evaluations. WGS has the potential to generate a large number of deterministic findings for which treatment options are limited. Hence, it is necessary to limit indications, in which WGS has proven medical evidence.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Pautas de la Práctica en Medicina
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Pruebas Genéticas
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Mapeo Cromosómico
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Tamizaje Neonatal
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Costos de la Atención en Salud
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Secuenciación de Nucleótidos de Alto Rendimiento
Tipo de estudio:
Health_economic_evaluation
/
Prognostic_studies
Límite:
Humans
/
Newborn
País/Región como asunto:
Europa
Idioma:
De
Revista:
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
Asunto de la revista:
SAUDE PUBLICA
Año:
2017
Tipo del documento:
Article