Emerging Role for Mammalian Target of Rapamycin in Male Fertility.

Oliveira, Pedro F; Cheng, C Y; Alves, Marco G

Oliveira, Pedro F; Cheng, C Y; Alves, Marco G.

Afiliación

Oliveira PF; Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal; Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal; Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.
Cheng CY; Population Council's Center for Biomedical Research, New York, USA.
Alves MG; Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal; CICS-UBI - Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal. Electronic address: alvesmarc@gmail.com.

Trends Endocrinol Metab ; 28(3): 165-167, 2017 03.

Article en En | MEDLINE | ID: mdl-28063768

ABSTRACT

ABSTRACT

Male fertility is modulated by environmental, endocrine, paracrine, and metabolic cues. Mammalian target of rapamycin (mTOR) coordinates many cellular events in response to those signals. Here, we discuss how the mTOR pathway integrates and mediates signals throughout the male reproductive system, acting as a central player in the control of spermatogenesis.

Asunto(s)

Infertilidad Masculina/metabolismo; Transducción de Señal/fisiología; Serina-Treonina Quinasas TOR/metabolismo; Humanos; Masculino; Células de Sertoli/metabolismo; Transducción de Señal/genética; Espermatogénesis/genética; Espermatogénesis/fisiología; Serina-Treonina Quinasas TOR/genética

Palabras clave

Sertoli cell; fertility; mTOR; spermatogenesis

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Transducción de Señal / Serina-Treonina Quinasas TOR / Infertilidad Masculina Límite: Humans / Male Idioma: En Revista: Trends Endocrinol Metab Asunto de la revista: ENDOCRINOLOGIA / METABOLISMO Año: 2017 Tipo del documento: Article País de afiliación: Portugal

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google