Inhibition of Inositol 1, 4, 5-Trisphosphate Receptor Induce Breast Cancer Cell Death Through Deregulated Autophagy and Cellular Bioenergetics.

Singh, Aru; Chagtoo, Megha; Tiwari, Swasti; George, Nelson; Chakravarti, Bandana; Khan, Sajid; Lakshmi, Sripada; Godbole, Madan M

Singh, Aru; Chagtoo, Megha; Tiwari, Swasti; George, Nelson; Chakravarti, Bandana; Khan, Sajid; Lakshmi, Sripada; Godbole, Madan M.

Afiliación

Singh A; Department of Molecular Medicine and Biotechnology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh 226014, India.
Chagtoo M; Department of Molecular Medicine and Biotechnology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh 226014, India.
Tiwari S; Department of Molecular Medicine and Biotechnology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh 226014, India.
George N; Endocrine Surgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh 226017, India.
Chakravarti B; Department of Molecular Medicine and Biotechnology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh 226014, India.
Khan S; Department of Endocrinology, Central Drug Research Institute, Lucknow, Uttar Pradesh 226031, India.
Lakshmi S; Department of Biochemistry, MS University Vadodara, Vadodara, Gujarat, India.
Godbole MM; Department of Molecular Medicine and Biotechnology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh 226014, India.

J Cell Biochem ; 118(8): 2333-2346, 2017 08.

Article en En | MEDLINE | ID: mdl-28106298

Asunto(s)

Neoplasias de la Mama/metabolismo; Receptores de Inositol 1,4,5-Trifosfato/metabolismo; Acetilcisteína/farmacología; Adenina/análogos & derivados; Adenina/farmacología; Autofagia/efectos de los fármacos; Autofagia/genética; Proteína 5 Relacionada con la Autofagia/antagonistas & inhibidores; Proteína 5 Relacionada con la Autofagia/genética; Proteína 5 Relacionada con la Autofagia/metabolismo; Western Blotting; Muerte Celular/efectos de los fármacos; Muerte Celular/genética; Línea Celular Tumoral; Metabolismo Energético/efectos de los fármacos; Metabolismo Energético/genética; Técnica del Anticuerpo Fluorescente; Humanos; Receptores de Inositol 1,4,5-Trifosfato/antagonistas & inhibidores; Células MCF-7; Macrólidos/farmacología; Potencial de la Membrana Mitocondrial/efectos de los fármacos; Proteínas Asociadas a Microtúbulos/genética; Proteínas Asociadas a Microtúbulos/metabolismo; ARN Interferente Pequeño/genética; ARN Interferente Pequeño/farmacología

Palabras clave

AUTOPHAGY; BIOENERGETICS; BREAST CANCER; CALCIUM CHANNELS; INSOSITOL 1,4,5 TRISPHOSPHATE RECEPTOR

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Receptores de Inositol 1,4,5-Trifosfato Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Cell Biochem Año: 2017 Tipo del documento: Article País de afiliación: India

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