Strenuous running exacerbates knee cartilage erosion induced by low amount of mono-iodoacetate in rats.
BMC Musculoskelet Disord
; 18(1): 36, 2017 01 25.
Article
en En
| MEDLINE
| ID: mdl-28122526
ABSTRACT
BACKGROUND:
It is still debated whether strenuous running in the inflammatory phase produces beneficial or harmful effect in rat knees. We examined (1) the dropout rate of rats during a 30-km running protocol, (2) influences of strenuous running and/or low amounts of mono-iodoacetate injection on cartilage, and (3) the effect of strenuous running on synovitis.METHODS:
Rats were forced to run 30 km over 6 weeks and the dropout rate was examined. One week after 0.1 mg mono-iodoacetate was injected into the right knee, rats were forced to run either 15 km or not run at all over 3 weeks, after which knee cartilage was evaluated. Synovium at the infrapatellar fat pad was also examined histologically.RESULTS:
Even though all 12 rats run up to 15 km, only 6 rats completed 30 km of running. Macroscopically, 0.1 mg mono-iodoacetate induced erosion at the tibial cartilage irrespective of 15 km of running. Histologically, 0.1 mg mono-iodoacetate induced loss of cartilage matrix in the tibial cartilage, and an additional 15 km of strenuous running significantly exacerbated the loss. Synovitis caused by mono-iodoacetate improved after running.CONCLUSIONS:
Only 50% of rats completed 30 km of running because of foot problems. Strenuous running further exacerbated tibial cartilage erosion but did not influence synovitis induced by mono-iodoacetate.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Carrera
/
Cartílago Articular
/
Yodoacetatos
/
Articulación de la Rodilla
Límite:
Animals
Idioma:
En
Revista:
BMC Musculoskelet Disord
Asunto de la revista:
FISIOLOGIA
/
ORTOPEDIA
Año:
2017
Tipo del documento:
Article
País de afiliación:
Japón