Anti-inflammatory 2-(2-phenylethyl)chromone derivatives from Chinese agarwood.
Fitoterapia
; 118: 49-55, 2017 Apr.
Article
en En
| MEDLINE
| ID: mdl-28237880
ABSTRACT
Five new 2-(2-phenylethyl)chromone derivatives (1-5), along with eleven known compounds (6-16) were isolated from Chinese agarwood. Their structures were elucidated by spectroscopic data (NMR, UV, IR, and MS) analyses and comparison of their spectroscopic and physical data with the literature values. The absolute configurations of 2-4 were determined by electronic circular dichroism (ECD) calculations. Compounds 2-4, 11, 12, and 15 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells with IC50 values in the range 1.6-7.3µM.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Flavonoides
/
Thymelaeaceae
/
Antiinflamatorios
Límite:
Animals
Idioma:
En
Revista:
Fitoterapia
Año:
2017
Tipo del documento:
Article