Pyrrolo[2,3-d]Pyrimidines as Kinase Inhibitors.
Curr Med Chem
; 24(19): 2059-2085, 2017.
Article
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| MEDLINE
| ID: mdl-28266267
ABSTRACT
The pyrrolo[2,3-d]pyrimidine nucleus is a deaza-isostere of adenine, the nitrogenous base of ATP, and is present in many ATP-competitive inhibitors of different kinases. In the last few years the number of articles and patents that have appeared involving this type of inhibitors has dramatically increased and some compounds have been approved for the treatment of inflammatory or myeloproliferative diseases. Other derivatives are currently being evaluated in clinical trials. This review deals with pyrrolo[2,3- d]pyrimidine derivatives active as kinase inhibitors that have been reported in the literature from 2011 to 2016, with a particular interest on the recently patented compounds. The molecules are classified depending on the inhibited kinase, focusing on their chemical structures.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Pirimidinas
/
Pirroles
/
Inhibidores de Proteínas Quinasas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Med Chem
Asunto de la revista:
QUIMICA
Año:
2017
Tipo del documento:
Article