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Six new furostanol glycosides from Smilax glauco-china and their cytotoxic activity.
Liu, Xing; Liang, Jian; Pan, Ling-Ling; Chen, Jian-Yong; Liu, Rong-Hua; Zhu, Gen-Hua; Huang, Hui-Lian; Shu, Ji-Cheng; Shao, Feng; Liang, Yong-Hong; Yu, Jiang-Li.
Afiliación
  • Liu X; a Key Laboratory of Modern Preparation of TCM , Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , China.
  • Liang J; a Key Laboratory of Modern Preparation of TCM , Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , China.
  • Pan LL; a Key Laboratory of Modern Preparation of TCM , Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , China.
  • Chen JY; b Gastroenterology Department , Jiangxi Province People Hospital , Nanchang 330006 , China.
  • Liu RH; a Key Laboratory of Modern Preparation of TCM , Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , China.
  • Zhu GH; a Key Laboratory of Modern Preparation of TCM , Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , China.
  • Huang HL; a Key Laboratory of Modern Preparation of TCM , Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , China.
  • Shu JC; a Key Laboratory of Modern Preparation of TCM , Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , China.
  • Shao F; a Key Laboratory of Modern Preparation of TCM , Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , China.
  • Liang YH; a Key Laboratory of Modern Preparation of TCM , Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , China.
  • Yu JL; a Key Laboratory of Modern Preparation of TCM , Ministry of Education, Jiangxi University of Traditional Chinese Medicine , Nanchang 330004 , China.
J Asian Nat Prod Res ; 19(8): 754-765, 2017 Aug.
Article en En | MEDLINE | ID: mdl-28276765
ABSTRACT
Six new steroidal saponins, namely glauco-chinaosides A-F, and one known compound were isolated from the tubers of Smilax glauco-china. Their structures were elucidated by a combination of spectroscopic analysis and hydrolysis followed by spectral and chromatographic analysis. Compounds 1-7 were tested in vitro for their cytotoxic activities against four human tumor cell lines (SH-SY5Y, SGC-7901, HCT-116, and Lovo). Compounds 1, 2, and 5 exhibited cytotoxic activity against SGC-7901, with IC50 values of 2.7, 11.5, and 6.8 µM, respectively.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Saponinas / Esteroles / Medicamentos Herbarios Chinos / Smilax / Glicósidos / Antineoplásicos Fitogénicos Límite: Humans Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Saponinas / Esteroles / Medicamentos Herbarios Chinos / Smilax / Glicósidos / Antineoplásicos Fitogénicos Límite: Humans Idioma: En Revista: J Asian Nat Prod Res Asunto de la revista: BOTANICA / QUIMICA Año: 2017 Tipo del documento: Article País de afiliación: China