Influence of protein fold stability on immunogenicity and its implications for vaccine design.

Scheiblhofer, Sandra; Laimer, Josef; Machado, Yoan; Weiss, Richard; Thalhamer, Josef

Scheiblhofer, Sandra; Laimer, Josef; Machado, Yoan; Weiss, Richard; Thalhamer, Josef.

Afiliación

Scheiblhofer S; a Department of Molecular Biology , University of Salzburg , Salzburg , Austria.
Laimer J; a Department of Molecular Biology , University of Salzburg , Salzburg , Austria.
Machado Y; a Department of Molecular Biology , University of Salzburg , Salzburg , Austria.
Weiss R; a Department of Molecular Biology , University of Salzburg , Salzburg , Austria.
Thalhamer J; a Department of Molecular Biology , University of Salzburg , Salzburg , Austria.

Expert Rev Vaccines ; 16(5): 479-489, 2017 May.

Article en En | MEDLINE | ID: mdl-28290225

Asunto(s)

Antígenos/química; Antígenos/inmunología; Proteínas Recombinantes/química; Proteínas Recombinantes/inmunología; Vacunas/inmunología; Animales; Modelos Animales de Enfermedad; Diseño de Fármacos; Estabilidad de Medicamentos; Humanos; Pliegue de Proteína

Palabras clave

Protein stability; conformational stability; destabilization; fold stability; immunogenicity; processing; protein variants; recombinant vaccines; stabilization

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Recombinantes / Vacunas / Antígenos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Expert Rev Vaccines Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Austria

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