Pharmacogenomic Advances in the Prediction and Prevention of Cutaneous Idiosyncratic Drug Reactions.
Clin Pharmacol Ther
; 102(1): 86-97, 2017 07.
Article
en En
| MEDLINE
| ID: mdl-28295240
ABSTRACT
Cutaneous idiosyncratic drug reactions (CIDRs) are usually unpredictable, ranging from mild maculopapular exanthema (MPE) to severe cutaneous adverse drug reactions (SCARs) such as drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). Increasing evidence suggests that HLA alleles are strongly associated with drug-induced-CIDRs. The pathomechanisms for CIDRs include genetic polymorphisms affecting complex immune-specific HLA/drug antigen/T-cell receptor interactions and drug metabolism. Pharmacogenomic tests to prevent CIDRs have been widely implemented in clinical practice in recent years.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Pruebas Genéticas
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Síndrome de Stevens-Johnson
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Variantes Farmacogenómicas
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Antígenos HLA
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Clin Pharmacol Ther
Año:
2017
Tipo del documento:
Article
País de afiliación:
Taiwán