The Pten-Parkin Axis: At the Nexus of Cancer and Neurodegeneration.

Ihle, Nathan T; Abraham, Robert T

Ihle, Nathan T; Abraham, Robert T.

Afiliación

Ihle NT; Oncology R&D Group, Pfizer Worldwide Research & Development, 10646/CB4, Science Center Drive, San Diego, CA 92121, USA.
Abraham RT; Oncology R&D Group, Pfizer Worldwide Research & Development, 10646/CB4, Science Center Drive, San Diego, CA 92121, USA. Electronic address: robert.abraham@pfizer.com.

Mol Cell ; 65(6): 959-960, 2017 Mar 16.

Article en En | MEDLINE | ID: mdl-28306509

ABSTRACT

ABSTRACT

The PARK2 gene encodes an ubiquitin E3 ligase that is involved in mitochondrial homeostasis and linked to Parkinson's disease. In this issue, Gupta et al. (2017) demonstrate that PARK2 expression is frequently reduced in human cancers and that this alteration leads to dysregulated PI3K signaling.

Asunto(s)

Fosfatidilinositol 3-Quinasas; Ubiquitina-Proteína Ligasas/genética; Humanos; Mitocondrias; Neoplasias; Enfermedad de Parkinson/genética; Ubiquitina

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Fosfatidilinositol 3-Quinasas / Ubiquitina-Proteína Ligasas Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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