[Pulmonary alveolar proteinosis: role of GM-CSF Antibodies]. / Proteinosis alveolar pulmonar: rol de los anticuerpo ANT-GM-CSF.
Rev Fac Cien Med Univ Nac Cordoba
; 74(1): 46-50, 2017.
Article
en Es
| MEDLINE
| ID: mdl-28379131
ABSTRACT
Pulmonary alveolar proteinosis is a rare illness characterized by alterations in the normal depuration of surfactants from the alveolar space in a process dependent of the granulocyte-monocyte colony stimulating factor (GM-CSF). The most of the patients develop antibodies that neutralize this factor, avoiding the normal homeostasis of surfactants. Therapeutic options include the total lung washes and administration of GM-CSF when the washes fail. Despite the contribution related with the knowledge about of the nature of the disease, the measurement of serum antibodies anti-GM-CSF is not a routine technique. We present a systematic review of this challenging disease.
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Base de datos:
MEDLINE
Asunto principal:
Proteinosis Alveolar Pulmonar
/
Autoanticuerpos
/
Factor Estimulante de Colonias de Granulocitos y Macrófagos
Tipo de estudio:
Systematic_reviews
Límite:
Humans
Idioma:
Es
Revista:
Rev Fac Cien Med Univ Nac Cordoba
Año:
2017
Tipo del documento:
Article