Adhesion-induced eosinophil cytolysis requires the receptor-interacting protein kinase 3 (RIPK3)-mixed lineage kinase-like (MLKL) signaling pathway, which is counterregulated by autophagy.

Radonjic-Hoesli, Susanne; Wang, Xiaoliang; de Graauw, Elisabeth; Stoeckle, Christina; Styp-Rekowska, Beata; Hlushchuk, Ruslan; Simon, Dagmar; Spaeth, Peter J; Yousefi, Shida; Simon, Hans-Uwe

Radonjic-Hoesli, Susanne; Wang, Xiaoliang; de Graauw, Elisabeth; Stoeckle, Christina; Styp-Rekowska, Beata; Hlushchuk, Ruslan; Simon, Dagmar; Spaeth, Peter J; Yousefi, Shida; Simon, Hans-Uwe.

Afiliación

Radonjic-Hoesli S; Institute of Pharmacology, University of Bern, Bern, Switzerland; Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Wang X; Institute of Pharmacology, University of Bern, Bern, Switzerland.
de Graauw E; Institute of Pharmacology, University of Bern, Bern, Switzerland.
Stoeckle C; Institute of Pharmacology, University of Bern, Bern, Switzerland.
Styp-Rekowska B; Institute of Anatomy, University of Bern, Bern, Switzerland.
Hlushchuk R; Institute of Anatomy, University of Bern, Bern, Switzerland.
Simon D; Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Spaeth PJ; Institute of Pharmacology, University of Bern, Bern, Switzerland.
Yousefi S; Institute of Pharmacology, University of Bern, Bern, Switzerland.
Simon HU; Institute of Pharmacology, University of Bern, Bern, Switzerland. Electronic address: hus@pki.unibe.ch.

J Allergy Clin Immunol ; 140(6): 1632-1642, 2017 Dec.

Article en En | MEDLINE | ID: mdl-28412393

Asunto(s)

Esofagitis Eosinofílica/inmunología; Eosinófilos/inmunología; Hipersensibilidad/inmunología; Proteínas Quinasas/metabolismo; Proteína Serina-Treonina Quinasas de Interacción con Receptores/metabolismo; Piel/inmunología; Autofagia; Adhesión Celular; Células Cultivadas; Complemento C3b/metabolismo; Citotoxicidad Inmunológica; Humanos; Inmunoglobulinas Intravenosas/metabolismo; Terapia Molecular Dirigida; Transducción de Señal

Palabras clave

Autophagy; RIP kinase; eosinophil cytolysis; eosinophilic disease; mixed lineage kinase-like; necroptosis; necrosis; non-apoptotic cell death; reactive oxygen species

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas Quinasas / Piel / Eosinófilos / Proteína Serina-Treonina Quinasas de Interacción con Receptores / Esofagitis Eosinofílica / Hipersensibilidad Límite: Humans Idioma: En Revista: J Allergy Clin Immunol Año: 2017 Tipo del documento: Article País de afiliación: Suiza

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