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Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells.
Zwergel, Clemens; Czepukojc, Brigitte; Evain-Bana, Emilie; Xu, Zhanjie; Stazi, Giulia; Mori, Mattia; Patsilinakos, Alexandros; Mai, Antonello; Botta, Bruno; Ragno, Rino; Bagrel, Denise; Kirsch, Gilbert; Meiser, Peter; Jacob, Claus; Montenarh, Mathias; Valente, Sergio.
Afiliación
  • Zwergel C; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185, Rome, Italy; Division of Bioorganic Chemistry, School of Pharmacy, Saarland State University, Campus, Bld. B2.1, 66123, Saarbrücken, Germany; Université de Lorraine, UMR CNRS 7565, Structure et Réacti
  • Czepukojc B; Medical Biochemistry and Molecular Biology, Saarland University, 66421, Homburg/Saar, Germany; Division of Bioorganic Chemistry, School of Pharmacy, Saarland State University, Campus, Bld. B2.1, 66123, Saarbrücken, Germany.
  • Evain-Bana E; Université de Lorraine, UMR CNRS 7565, Structure et Réactivité des Systèmes Moléculaires Complexes, Equipe 5 (MIC), Campus Bridoux, rue du Général Delestraint, 57070, Metz Cedex, France.
  • Xu Z; Université de Lorraine, UMR CNRS 7565, Structure et Réactivité des Systèmes Moléculaires Complexes, Equipe 3 (HECRIN), 1 Boulevard Arago, 57078, Metz Technopôle, France; Division of Bioorganic Chemistry, School of Pharmacy, Saarland State University, Campus, Bld. B2.1, 66123, Saarbrücken, Germany; U
  • Stazi G; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185, Rome, Italy.
  • Mori M; Italian Institute of Technology, Center for Life Nano Science@Sapienza, Via Regina Elena 291, 00161, Rome, Italy.
  • Patsilinakos A; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185, Rome, Italy; Rome Center for Molecular Design, Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185, Rome, Italy; Alchemical Dynamics srl, P. le A. Moro 5
  • Mai A; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185, Rome, Italy; Istituto Pasteur- Fondazione Cenci Bolognetti, Sapienza University of Rome, Via Regina Elena 291, 00161, Rome, Italy.
  • Botta B; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185, Rome, Italy.
  • Ragno R; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185, Rome, Italy; Rome Center for Molecular Design, Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185, Rome, Italy; Alchemical Dynamics srl, P. le A. Moro 5
  • Bagrel D; Université de Lorraine, UMR CNRS 7565, Structure et Réactivité des Systèmes Moléculaires Complexes, Equipe 5 (MIC), Campus Bridoux, rue du Général Delestraint, 57070, Metz Cedex, France.
  • Kirsch G; Université de Lorraine, UMR CNRS 7565, Structure et Réactivité des Systèmes Moléculaires Complexes, Equipe 3 (HECRIN), 1 Boulevard Arago, 57078, Metz Technopôle, France. Electronic address: gilbert.kirsch@univ-lorraine.fr.
  • Meiser P; Ursapharm Arzneimittel GmbH, Industriestraße 35, 66129, Saarbrücken, Germany.
  • Jacob C; Division of Bioorganic Chemistry, School of Pharmacy, Saarland State University, Campus, Bld. B2.1, 66123, Saarbrücken, Germany.
  • Montenarh M; Medical Biochemistry and Molecular Biology, Saarland University, 66421, Homburg/Saar, Germany. Electronic address: Mathias.Montenarh@uniklinikum-saarland.de.
  • Valente S; Department of Drug Chemistry and Technologies, Sapienza University of Rome, P. le A. Moro 5, 00185, Rome, Italy. Electronic address: Sergio.valente@uniroma1.it.
Eur J Med Chem ; 134: 316-333, 2017 Jul 07.
Article en En | MEDLINE | ID: mdl-28431339
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Cumarinas / Fosfatasas cdc25 / Antineoplásicos Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2017 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Cumarinas / Fosfatasas cdc25 / Antineoplásicos Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2017 Tipo del documento: Article