CF2H, a Hydrogen Bond Donor.
J Am Chem Soc
; 139(27): 9325-9332, 2017 07 12.
Article
en En
| MEDLINE
| ID: mdl-28576078
ABSTRACT
The CF2H group, a potential surrogate for the OH group, can act as an unusual hydrogen bond donor, as confirmed by crystallographic, spectroscopic, and computational methods. Here, we demonstrate the bioisosterism of the OH and CF2H groups and the important roles of CF2-H···O hydrogen bonds in influencing intermolecular interactions and conformational preferences. Experimental evidence, corroborated by theory, reveals the distinctive nature of CF2H hydrogen bonding interactions relative to their normal OH hydrogen bonding counterparts.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Radical Hidroxilo
/
Hidrocarburos Fluorados
Idioma:
En
Revista:
J Am Chem Soc
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos