Impurity profiling of liothyronine sodium by means of reversed phase HPLC, high resolution mass spectrometry, on-line H/D exchange and UV/Vis absorption.

Ruggenthaler, M; Grass, J; Schuh, W; Huber, C G; Reischl, R J

Ruggenthaler, M; Grass, J; Schuh, W; Huber, C G; Reischl, R J.

Afiliación

Ruggenthaler M; SANDOZ GmbH, Biochemiestraße 10, A-6250 Kundl/Tirol, Austria; Department of Molecular Biology, Division of Chemistry and Bioanalytics, University of Salzburg, Hellbrunner Straße 34, A-5020 Salzburg, Austria.
Grass J; SANDOZ GmbH, Biochemiestraße 10, A-6250 Kundl/Tirol, Austria.
Schuh W; SANDOZ GmbH, Biochemiestraße 10, A-6250 Kundl/Tirol, Austria.
Huber CG; Department of Molecular Biology, Division of Chemistry and Bioanalytics, University of Salzburg, Hellbrunner Straße 34, A-5020 Salzburg, Austria.
Reischl RJ; Department of Molecular Biology, Division of Chemistry and Bioanalytics, University of Salzburg, Hellbrunner Straße 34, A-5020 Salzburg, Austria. Electronic address: roland.reischl@sbg.ac.at.

J Pharm Biomed Anal ; 143: 147-158, 2017 Sep 05.

Article en En | MEDLINE | ID: mdl-28599168

Asunto(s)

Triyodotironina/análisis; Cromatografía Líquida de Alta Presión; Deuterio; Contaminación de Medicamentos; Hidrógeno; Espectrometría de Masas; Sodio

Palabras clave

API analysis; H/D exchange; HDX; HRMS; HRMS/MS; Hormone deficiency; Hypothyroidism; Impurity profiling; LT3Na; Liothyronine; Liothyronine sodium; Thyroxine; UV Vis spectroscopy

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Triyodotironina Idioma: En Revista: J Pharm Biomed Anal Año: 2017 Tipo del documento: Article País de afiliación: Austria

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