The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways.

Lu, Shi-Yu; Wang, Chang-Yuan; Jin, Yue; Meng, Qiang; Liu, Qi; Liu, Zhi-Hao; Liu, Ke-Xin; Sun, Hui-Jun; Liu, Mo-Zhen

Lu, Shi-Yu; Wang, Chang-Yuan; Jin, Yue; Meng, Qiang; Liu, Qi; Liu, Zhi-Hao; Liu, Ke-Xin; Sun, Hui-Jun; Liu, Mo-Zhen.

Afiliación

Lu SY; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Wang CY; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Jin Y; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Meng Q; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Liu Q; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Liu ZH; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Liu KX; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China.
Sun HJ; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, China. sunhuijun@dlmedu.edu.cn.
Liu MZ; Department of Orthopaedics, First Affiliated Hospital, Dalian Medical University, Dalian, China. mozhenliu@hotmail.com.

Sci Rep ; 7(1): 3331, 2017 06 13.

Article en En | MEDLINE | ID: mdl-28611356

Asunto(s)

Antioxidantes/farmacología; Osteogénesis/efectos de los fármacos; Osteoporosis/tratamiento farmacológico; Transducción de Señal; Ácido Tióctico/farmacología; Animales; Antioxidantes/uso terapéutico; Línea Celular; Femenino; Glucocorticoides/toxicidad; MAP Quinasa Quinasa 4/metabolismo; NADPH Oxidasa 4/metabolismo; FN-kappa B/metabolismo; Osteoporosis/etiología; Osteoporosis/metabolismo; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Ratas; Ratas Sprague-Dawley; Ácido Tióctico/uso terapéutico

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Osteogénesis / Osteoporosis / Transducción de Señal / Ácido Tióctico / Antioxidantes Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2017 Tipo del documento: Article País de afiliación: China

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