Effect of hydroxypropyl methyl cellulose phthalate coating on digestive stability and intestinal transport of green tea catechins.
Integr Med Res
; 3(1): 34-37, 2014 Mar.
Article
en En
| MEDLINE
| ID: mdl-28664076
ABSTRACT
BACKGROUND:
The purpose of this study was to investigate the effect of hydroxypropyl methyl cellulose phthalate (HPMCP) coating on the digestive stability and intestinal transport of green tea catechins (GTCs).METHODS:
Two types of HPMCP coating were prepared one type with size smaller than 500 µm (S-HPMCP) and the other with size larger than 500 µm (L-HPMCP). An in vitro gastrointestinal model system coupled with Caco-2 cells was used for estimating the bioavailability of GTCs. Ultraperformance liquid chromatography with a photodiode array detector was performed to analyze GTCs.RESULTS:
The digestive stability of GTCs was enhanced up to 33.73% and 35.28% for S-HPMCP and L-HPMCP, respectively. Intestinal transport of the GTCs was increased to 22.98% and 23.23% for S-HPMCP and L-HPMCP, respectively. Overall, the bioavailability of GTCs increased by 4.08 and 11.71 times for S-HPMCP and L-HPMCP, respectively.CONCLUSION:
The results of this study confirm that coating with HPMCP could be a way to improve the digestive stability and intestinal transport of GTCs.
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Base de datos:
MEDLINE
Idioma:
En
Revista:
Integr Med Res
Año:
2014
Tipo del documento:
Article