Guillain-Barré syndrome in association with antitumour necrosis factor therapy: a case of mistaken identity.
BMJ Case Rep
; 20172017 Jul 05.
Article
en En
| MEDLINE
| ID: mdl-28679512
ABSTRACT
Guillain-Barré syndrome (GBS) is an immune-mediated disease characterised by evolving ascending limb weakness, sensory loss and areflexia. Two-thirds of GBS cases are associated with preceding infection. However, GBS has also been described in association with antitumour necrosis factor (TNF) therapies including infliximab and adalimumab for chronic inflammatory disorders such as rheumatoid arthritis, ankylosing spondylitis and inflammatory bowel disease. We present the case of a patient who developed GBS while undergoing treatment with adalimumab in combination with azathioprine for severe fistulising Crohn's disease, and review the literature on neurological adverse events that occur in association with anti-TNF therapy. We also propose an approach to the optimal management of patients who develop debilitating neurological sequelae in the setting of anti-TNF therapy.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Azatioprina
/
Enfermedad de Crohn
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Factor de Necrosis Tumoral alfa
/
Síndrome de Guillain-Barré
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Adalimumab
/
Inmunosupresores
/
Antiinflamatorios
Tipo de estudio:
Risk_factors_studies
Límite:
Adult
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Humans
/
Male
Idioma:
En
Revista:
BMJ Case Rep
Año:
2017
Tipo del documento:
Article
País de afiliación:
Australia