Neem leaf glycoprotein generates superior tumor specific central memory CD8<sup>+</sup> T cells than cyclophosphamide that averts post-surgery solid sarcoma recurrence.

Ghosh, Sarbari; Sarkar, Madhurima; Ghosh, Tithi; Guha, Ipsita; Bhuniya, Avishek; Saha, Akata; Dasgupta, Shayani; Barik, Subhasis; Bose, Anamika; Baral, Rathindranath

Neem leaf glycoprotein generates superior tumor specific central memory CD8⁺ T cells than cyclophosphamide that averts post-surgery solid sarcoma recurrence.

Ghosh, Sarbari; Sarkar, Madhurima; Ghosh, Tithi; Guha, Ipsita; Bhuniya, Avishek; Saha, Akata; Dasgupta, Shayani; Barik, Subhasis; Bose, Anamika; Baral, Rathindranath.

Afiliación

Ghosh S; Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute (CNCI), 37, S. P. Mukherjee Road, Kolkata 700026, India.
Sarkar M; Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute (CNCI), 37, S. P. Mukherjee Road, Kolkata 700026, India.
Ghosh T; Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute (CNCI), 37, S. P. Mukherjee Road, Kolkata 700026, India.
Guha I; Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute (CNCI), 37, S. P. Mukherjee Road, Kolkata 700026, India.
Bhuniya A; Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute (CNCI), 37, S. P. Mukherjee Road, Kolkata 700026, India.
Saha A; Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute (CNCI), 37, S. P. Mukherjee Road, Kolkata 700026, India.
Dasgupta S; Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute (CNCI), 37, S. P. Mukherjee Road, Kolkata 700026, India.
Barik S; Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute (CNCI), 37, S. P. Mukherjee Road, Kolkata 700026, India.
Bose A; Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute (CNCI), 37, S. P. Mukherjee Road, Kolkata 700026, India.
Baral R; Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute (CNCI), 37, S. P. Mukherjee Road, Kolkata 700026, India. Electronic address: baralrathin@hotmail.com.

Vaccine ; 35(34): 4421-4429, 2017 08 03.

Article en En | MEDLINE | ID: mdl-28684164

Asunto(s)

Azadirachta/química; Linfocitos T CD8-positivos/inmunología; Glicoproteínas/inmunología; Memoria Inmunológica; Recurrencia Local de Neoplasia/prevención & control; Extractos Vegetales/inmunología; Sarcoma/inmunología; Animales; Antígenos de Neoplasias; Línea Celular Tumoral; Ciclofosfamida/administración & dosificación; Ciclofosfamida/inmunología; Ciclofosfamida/uso terapéutico; Citotoxicidad Inmunológica; Glicoproteínas/uso terapéutico; Inmunoterapia; Ratones; Recurrencia Local de Neoplasia/inmunología; Recurrencia Local de Neoplasia/cirugía; Extractos Vegetales/administración & dosificación; Extractos Vegetales/química; Extractos Vegetales/uso terapéutico; Hojas de la Planta/química; Hojas de la Planta/inmunología; Sarcoma/prevención & control; Sarcoma/cirugía; Vía de Señalización Wnt; beta Catenina/genética

Palabras clave

Central memory CD8(+) T cells; Neem leaf glycoprotein; Sarcoma recurrence; Tumor surgery; Wnt signalling

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Sarcoma / Extractos Vegetales / Glicoproteínas / Linfocitos T CD8-positivos / Azadirachta / Memoria Inmunológica / Recurrencia Local de Neoplasia Límite: Animals Idioma: En Revista: Vaccine Año: 2017 Tipo del documento: Article País de afiliación: India

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