Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex.

Okamoto, Naoki; Mizote, Keisuke; Honda, Hiroe; Saeki, Akinori; Watanabe, Yasuharu; Yamaguchi-Miyamoto, Tomomi; Fukui, Ryutaro; Tanimura, Natsuko; Motoi, Yuji; Akashi-Takamura, Sachiko; Kato, Tatsuhisa; Fujishita, Shigeto; Kimura, Takahito; Ohto, Umeharu; Shimizu, Toshiyuki; Hirokawa, Takatsugu; Miyake, Kensuke; Fukase, Koichi; Fujimoto, Yukari; Nagai, Yoshinori; Takatsu, Kiyoshi

Okamoto, Naoki; Mizote, Keisuke; Honda, Hiroe; Saeki, Akinori; Watanabe, Yasuharu; Yamaguchi-Miyamoto, Tomomi; Fukui, Ryutaro; Tanimura, Natsuko; Motoi, Yuji; Akashi-Takamura, Sachiko; Kato, Tatsuhisa; Fujishita, Shigeto; Kimura, Takahito; Ohto, Umeharu; Shimizu, Toshiyuki; Hirokawa, Takatsugu; Miyake, Kensuke; Fukase, Koichi; Fujimoto, Yukari; Nagai, Yoshinori; Takatsu, Kiyoshi.

Afiliación

Okamoto N; From the Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama 930-0194.
Mizote K; the Teika Pharmaceutical Co., Ltd., 1-3-27 Arakawa, Toyama-shi, Toyama 930-0982.
Honda H; the Laboratory of Natural Product Chemistry, Department of Chemistry, School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043.
Saeki A; From the Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama 930-0194.
Watanabe Y; the Toyama Prefectural Institute for Pharmaceutical Research, 17-1 Nakataikouyama, Imizu City, Toyama 939-0363.
Yamaguchi-Miyamoto T; the Laboratory of Natural Product Chemistry, Department of Chemistry, School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043.
Fukui R; From the Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, 2630 Sugitani, Toyama-shi, Toyama 930-0194.
Tanimura N; the Toyama Prefectural Institute for Pharmaceutical Research, 17-1 Nakataikouyama, Imizu City, Toyama 939-0363.
Motoi Y; the Division of Innate Immunity, Department of Microbiology and Immunology.
Akashi-Takamura S; the Division of Innate Immunity, Department of Microbiology and Immunology.
Kato T; the Division of Innate Immunity, Department of Microbiology and Immunology.
Fujishita S; the Department of Microbiology and Immunology, School of Medicine, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195.
Kimura T; the Teika Pharmaceutical Co., Ltd., 1-3-27 Arakawa, Toyama-shi, Toyama 930-0982.
Ohto U; the Teika Pharmaceutical Co., Ltd., 1-3-27 Arakawa, Toyama-shi, Toyama 930-0982.
Shimizu T; the Teika Pharmaceutical Co., Ltd., 1-3-27 Arakawa, Toyama-shi, Toyama 930-0982.
Hirokawa T; the Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033.
Miyake K; the Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033.
Fukase K; the Molecular Profiling Research Center for Drug Discovery, AIST, 2-3-26 Aomi, Koto-ku, Tokyo 135-0064.
Fujimoto Y; the Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575.
Nagai Y; the Division of Innate Immunity, Department of Microbiology and Immunology.
Takatsu K; the Laboratory of Innate Immunity, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639.

J Biol Chem ; 292(37): 15378-15394, 2017 09 15.

Article en En | MEDLINE | ID: mdl-28754693

Asunto(s)

Células Dendríticas/efectos de los fármacos; Inmunidad Innata/efectos de los fármacos; Antígeno 96 de los Linfocitos/agonistas; Macrófagos/efectos de los fármacos; Modelos Inmunológicos; Receptor Toll-Like 4/agonistas; Animales; Sitios de Unión; Células de la Médula Ósea/citología; Células de la Médula Ósea/efectos de los fármacos; Células de la Médula Ósea/inmunología; Células de la Médula Ósea/metabolismo; Línea Celular; Células Cultivadas; Biología Computacional; Células Dendríticas/inmunología; Células Dendríticas/metabolismo; Diseño de Fármacos; Humanos; Ligandos; Antígeno 96 de los Linfocitos/química; Antígeno 96 de los Linfocitos/genética; Antígeno 96 de los Linfocitos/metabolismo; Macrófagos/citología; Macrófagos/inmunología; Macrófagos/metabolismo; Ratones Endogámicos C57BL; Ratones Noqueados; Simulación del Acoplamiento Molecular; Fosforilación; Piridonas/química; Piridonas/farmacología; Proteínas Recombinantes de Fusión/química; Proteínas Recombinantes de Fusión/metabolismo; Organismos Libres de Patógenos Específicos; Relación Estructura-Actividad; Receptor Toll-Like 4/química; Receptor Toll-Like 4/genética; Receptor Toll-Like 4/metabolismo

Palabras clave

NF-κB (NF-KB); TLR4/MD-2; adjuvant; dendritic cell; innate immunity; macrophage; toll-like receptor (TLR)

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Células Dendríticas / Modelos Inmunológicos / Antígeno 96 de los Linfocitos / Receptor Toll-Like 4 / Inmunidad Innata / Macrófagos Tipo de estudio: Prognostic_studies Idioma: En Revista: J Biol Chem Año: 2017 Tipo del documento: Article

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