Osteoporosis following heart transplantation and immunosuppressive therapy.
Transplant Rev (Orlando)
; 31(4): 232-239, 2017 10.
Article
en En
| MEDLINE
| ID: mdl-28865930
ABSTRACT
Heart transplantation (HT) remains the ultimate final therapy for patients with end-stage heart failure, who despite optimal medical and surgical treatments exhibit severe symptoms. To prevent rejection of the transplanted organ, HT patients require life-long immunosuppressive therapy. The goal of the immunosuppression is to minimise the risk of immune-mediated graft rejection, while avoiding clinical side-effects. Current immunosuppressive agents have yielded good survival outcome, however, complications of the immunosuppressive therapy, such as impaired bone strength and increased fracture risk, are common among HT patients rendering increased morbidity and mortality rates. The main aim of the present review was to summarise current knowledge on bone strength impairment after HT and concomitant immunosuppressive therapy.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Osteoporosis
/
Inmunología del Trasplante
/
Trasplante de Corazón
/
Inmunosupresores
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Transplant Rev (Orlando)
Asunto de la revista:
TRANSPLANTE
Año:
2017
Tipo del documento:
Article