Progress towards the total synthesis of hamigerans C and D: a direct approach to an elaborated 6-7-5 carbocyclic core.
J Antibiot (Tokyo)
; 71(2): 263-267, 2018 02.
Article
en En
| MEDLINE
| ID: mdl-28874851
ABSTRACT
The hamigeran family of natural products has been the target of numerous synthetic efforts because of its biological activity and interesting structural properties. Herein, we disclose our efforts toward the synthesis of hamigerans C and D, unique among the initially isolated members because of their 6-7-5 carbocyclic core. Our approach directly targets this tricyclic motif by sequential Negishi and Heck coupling reactions, yielding an advanced intermediate with all necessary carbons and sufficient functionality poised for completion of the synthesis of these two natural products.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Azulenos
/
Antineoplásicos
Límite:
Animals
Idioma:
En
Revista:
J Antibiot (Tokyo)
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos