Aptamer Oligonucleotides as Potential Therapeutics in Hematologic Diseases.
Mini Rev Med Chem
; 19(10): 788-795, 2019.
Article
en En
| MEDLINE
| ID: mdl-28969551
ABSTRACT
Aptamers are single-stranded DNA or RNA oligonucleotides generated by a novel in vitro selection technique termed Systematic evolution of ligands by exponential enrichment (SELEX). During the past two decades, various aptamer drugs have been developed and many of them have entered into clinical trials. In the present review, we focus on aptamers as potential therapeutics for hematological diseases, including anemia of chronic inflammation (ACI) and anemia of chronic disease (ACD), hemophilia, thrombotic thrombocytopenic purpura (TTP) or VWD type-2B, and sickle cell disease (SCD), in particular, those that have entered into clinical trials.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Oligonucleótidos
/
Aptámeros de Nucleótidos
/
Enfermedades Hematológicas
Límite:
Humans
Idioma:
En
Revista:
Mini Rev Med Chem
Asunto de la revista:
QUIMICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
China