Selection and monitoring of patients with metastatic castration-resistant prostate cancer for treatment with radium-223.
Clin Transl Oncol
; 20(6): 679-686, 2018 Jun.
Article
en En
| MEDLINE
| ID: mdl-29098556
ABSTRACT
Despite the improvement provided by androgenic suppression in the treatment of prostate cancer, most of tumors develop resistance to castration. However, new therapies have demonstrated an increase in patient survival such as radium-223 (Ra-223), an alpha emitter and calcium mimetic with the capability of targeting osteoblastic metastatic lesions. According to results of the ALSYMPCA phase III trial, Ra-223 has demonstrated its activity by improving symptoms and survival of patients with metastatic castration-resistant prostate cancer (mCRPC), symptomatic bone metastases, and no known visceral metastatic disease, without interfering with subsequent treatments. This review examines the key evidence to establish the best patient selection criteria to use Ra-223, how to assess the response to treatment, treatment-related toxicity, and follow-up, but also current research regarding imaging techniques and biomarkers to assess the efficacy of Ra-223. Finally, we briefly describe the clinical trials that are currently ongoing with Ra-223.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Óseas
/
Radio (Elemento)
/
Selección de Paciente
/
Neoplasias de la Próstata Resistentes a la Castración
Tipo de estudio:
Prognostic_studies
Límite:
Humans
/
Male
Idioma:
En
Revista:
Clin Transl Oncol
Año:
2018
Tipo del documento:
Article
País de afiliación:
España