Testosterone Pathway Genetic Polymorphisms in Relation to Primary Open-Angle Glaucoma: An Analysis in Two Large Datasets.
Invest Ophthalmol Vis Sci
; 59(2): 629-636, 2018 02 01.
Article
en En
| MEDLINE
| ID: mdl-29392307
ABSTRACT
Purpose:
Sex hormones may be associated with primary open-angle glaucoma (POAG), although the mechanisms are unclear. We previously observed that gene variants involved with estrogen metabolism were collectively associated with POAG in women but not men; here we assessed gene variants related to testosterone metabolism collectively and POAG risk.Methods:
We used two datasets one from the United States (3853 cases and 33,480 controls) and another from Australia (1155 cases and 1992 controls). Both datasets contained densely called genotypes imputed to the 1000 Genomes reference panel. We used pathway- and gene-based approaches with Pathway Analysis by Randomization Incorporating Structure (PARIS) software to assess the overall association between a panel of single nucleotide polymorphisms (SNPs) in testosterone metabolism genes and POAG. In sex-stratified analyses, we evaluated POAG overall and POAG subtypes defined by maximum IOP (high-tension [HTG] or normal tension glaucoma [NTG]).Results:
In the US dataset, the SNP panel was not associated with POAG (permuted P = 0.77), although there was an association in the Australian sample (permuted P = 0.018). In both datasets, the SNP panel was associated with POAG in men (permuted P ≤ 0.033) and not women (permuted P ≥ 0.42), but in gene-based analyses, there was no consistency on the main genes responsible for these findings. In both datasets, the testosterone pathway association with HTG was significant (permuted P ≤ 0.011), but again, gene-based analyses showed no consistent driver gene associations.Conclusions:
Collectively, testosterone metabolism pathway SNPs were consistently associated with the high-tension subtype of POAG in two datasets.
Texto completo:
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Base de datos:
MEDLINE
Asunto principal:
Testosterona
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Glaucoma de Ángulo Abierto
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Polimorfismo de Nucleótido Simple
/
Redes y Vías Metabólicas
Tipo de estudio:
Clinical_trials
Límite:
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Invest Ophthalmol Vis Sci
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos