Involvement of PKA/DARPP-32/PP1&#945; and ß- arrestin/Akt/GSK-3ß Signaling in Cadmium-Induced DA-D2 Receptor-Mediated Motor Dysfunctions: Protective Role of Quercetin.

Gupta, Richa; Shukla, Rajendra K; Pandey, Ankita; Sharma, Tanuj; Dhuriya, Yogesh K; Srivastava, Pranay; Singh, Manjul P; Siddiqi, Mohammad Imran; Pant, Aditya B; Khanna, Vinay K

Involvement of PKA/DARPP-32/PP1α and ß- arrestin/Akt/GSK-3ß Signaling in Cadmium-Induced DA-D2 Receptor-Mediated Motor Dysfunctions: Protective Role of Quercetin.

Gupta, Richa; Shukla, Rajendra K; Pandey, Ankita; Sharma, Tanuj; Dhuriya, Yogesh K; Srivastava, Pranay; Singh, Manjul P; Siddiqi, Mohammad Imran; Pant, Aditya B; Khanna, Vinay K.

Afiliación

Gupta R; Developmental Toxicology Laboratory, Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31 Mahatma Gandhi Marg, Lucknow, 226 001, Uttar Pradesh, India.
Shukla RK; School of Pharmacy, Babu Banarsi Das University, Faizabad Road, Lucknow, 226 028, Uttar Pradesh, India.
Pandey A; Developmental Toxicology Laboratory, Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31 Mahatma Gandhi Marg, Lucknow, 226 001, Uttar Pradesh, India.
Sharma T; Developmental Toxicology Laboratory, Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31 Mahatma Gandhi Marg, Lucknow, 226 001, Uttar Pradesh, India.
Dhuriya YK; Molecular and Structural Biology, CSIR-Central Drug Research Institute, Sitapur Road, Sector 10, Jankipuram Extension, Lucknow, 226 031, Uttar Pradesh, India.
Srivastava P; Developmental Toxicology Laboratory, Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31 Mahatma Gandhi Marg, Lucknow, 226 001, Uttar Pradesh, India.
Singh MP; Developmental Toxicology Laboratory, Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31 Mahatma Gandhi Marg, Lucknow, 226 001, Uttar Pradesh, India.
Siddiqi MI; School of Pharmacy, Babu Banarsi Das University, Faizabad Road, Lucknow, 226 028, Uttar Pradesh, India.
Pant AB; Molecular and Structural Biology, CSIR-Central Drug Research Institute, Sitapur Road, Sector 10, Jankipuram Extension, Lucknow, 226 031, Uttar Pradesh, India.
Khanna VK; Developmental Toxicology Laboratory, Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research, Vishvigyan Bhawan, 31 Mahatma Gandhi Marg, Lucknow, 226 001, Uttar Pradesh, India.

Sci Rep ; 8(1): 2528, 2018 02 06.

Article en En | MEDLINE | ID: mdl-29410441

Asunto(s)

Antioxidantes/farmacología; Cadmio/toxicidad; Cuerpo Estriado/efectos de los fármacos; Cuerpo Estriado/patología; Dopamina/metabolismo; Trastornos del Movimiento; Quercetina/farmacología; Receptores de Dopamina D2/metabolismo; Animales; Antioxidantes/uso terapéutico; Cuerpo Estriado/metabolismo; Proteínas Quinasas Dependientes de AMP Cíclico/metabolismo; Fosfoproteína 32 Regulada por Dopamina y AMPc/metabolismo; Glucógeno Sintasa Quinasa 3 beta/metabolismo; Masculino; Trastornos del Movimiento/etiología; Trastornos del Movimiento/prevención & control; Células PC12; Proteína Fosfatasa 1/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Quercetina/uso terapéutico; Ratas; Ratas Wistar; Transducción de Señal/efectos de los fármacos; Sinapsis/efectos de los fármacos; Sinapsis/patología; Transmisión Sináptica/efectos de los fármacos; beta-Arrestinas/metabolismo

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Quercetina / Cadmio / Dopamina / Receptores de Dopamina D2 / Cuerpo Estriado / Trastornos del Movimiento / Antioxidantes Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: India

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