Exome sequencing of primary breast cancers with paired metastatic lesions reveals metastasis-enriched mutations in the A-kinase anchoring protein family (AKAPs).

Kjällquist, Una; Erlandsson, Rikard; Tobin, Nicholas P; Alkodsi, Amjad; Ullah, Ikram; Stålhammar, Gustav; Karlsson, Eva; Hatschek, Thomas; Hartman, Johan; Linnarsson, Sten; Bergh, Jonas

Kjällquist, Una; Erlandsson, Rikard; Tobin, Nicholas P; Alkodsi, Amjad; Ullah, Ikram; Stålhammar, Gustav; Karlsson, Eva; Hatschek, Thomas; Hartman, Johan; Linnarsson, Sten; Bergh, Jonas.

Afiliación

Kjällquist U; Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute and University Hospital, Stockholm, Sweden. una.kjallquist@ki.se.
Erlandsson R; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden. una.kjallquist@ki.se.
Tobin NP; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
Alkodsi A; Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute and University Hospital, Stockholm, Sweden.
Ullah I; Research Programs Unit, Genome-Scale Biology and Medicum, University of Helsinki, Helsinki, Finland.
Stålhammar G; Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute and University Hospital, Stockholm, Sweden.
Karlsson E; Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute and University Hospital, Stockholm, Sweden.
Hatschek T; Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute and University Hospital, Stockholm, Sweden.
Hartman J; Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute and University Hospital, Stockholm, Sweden.
Linnarsson S; Department of Oncology and Pathology, Cancer Center Karolinska, Karolinska Institute and University Hospital, Stockholm, Sweden.
Bergh J; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

BMC Cancer ; 18(1): 174, 2018 02 12.

Article en En | MEDLINE | ID: mdl-29433456

Asunto(s)

Proteínas de Anclaje a la Quinasa A/genética; Biomarcadores de Tumor; Neoplasias de la Mama/genética; Neoplasias de la Mama/patología; Familia de Multigenes; Mutación; Proteínas de Anclaje a la Quinasa A/metabolismo; Neoplasias de la Mama/metabolismo; Estudios de Cohortes; Variaciones en el Número de Copia de ADN; Femenino; Regulación Neoplásica de la Expresión Génica; Estudios de Asociación Genética; Humanos; Pérdida de Heterocigocidad; Metástasis de la Neoplasia/genética; Estadificación de Neoplasias; Secuenciación del Exoma

Palabras clave

A-kinase anchoring proteins; AKAP; Breast cancer; Exome sequencing; Metastasis; Somatic mutations

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Biomarcadores de Tumor / Familia de Multigenes / Proteínas de Anclaje a la Quinasa A / Mutación Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans Idioma: En Revista: BMC Cancer Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: Suecia

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