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Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway.
Palam, Lakshmi Reddy; Mali, Raghuveer Singh; Ramdas, Baskar; Srivatsan, Sridhar Nonavinkere; Visconte, Valeria; Tiu, Ramon V; Vanhaesebroeck, Bart; Roers, Axel; Gerbaulet, Alexander; Xu, Mingjiang; Janga, Sarath Chandra; Takemoto, Clifford M; Paczesny, Sophie; Kapur, Reuben.
Afiliación
  • Palam LR; Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Mali RS; Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Ramdas B; Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Srivatsan SN; School of Informatics and Computing, Indiana University & Purdue University, Indianapolis, Indiana, USA.
  • Visconte V; Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Tiu RV; Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Vanhaesebroeck B; University College London Cancer Institute, London, United Kingdom.
  • Roers A; Institute for Immunology, Dresden, Germany.
  • Gerbaulet A; Institute for Immunology, Dresden, Germany.
  • Xu M; Sylvester Comprehensive Cancer Center, Department of Biochemistry & Molecular Biology, University of Miami School of Medicine, Miami, Florida, USA.
  • Janga SC; School of Informatics and Computing, Indiana University & Purdue University, Indianapolis, Indiana, USA.
  • Takemoto CM; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
  • Paczesny S; Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland, USA.
  • Kapur R; Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA.
JCI Insight ; 3(4)2018 02 22.
Article en En | MEDLINE | ID: mdl-29467326
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Mastocitosis / Regulación Neoplásica de la Expresión Génica / Transformación Celular Neoplásica / Proteínas Proto-Oncogénicas / Proteínas Proto-Oncogénicas c-kit / Epigénesis Genética / Proteínas de Unión al ADN / Mastocitos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: JCI Insight Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Mastocitosis / Regulación Neoplásica de la Expresión Génica / Transformación Celular Neoplásica / Proteínas Proto-Oncogénicas / Proteínas Proto-Oncogénicas c-kit / Epigénesis Genética / Proteínas de Unión al ADN / Mastocitos Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: JCI Insight Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos