Small-scale production of 67Cu for a preclinical study via the 64Ni(α, p)67Cu channel.
Nucl Med Biol
; 59: 56-60, 2018 04.
Article
en En
| MEDLINE
| ID: mdl-29475187
ABSTRACT
INTRODUCTION:
Copper-67 is an attractive beta emitter for targeted radionuclide therapy. However, the availability of 67Cu limits its potential use in a wide range of applications. In this study, we propose an easy small-scale production of 67Cu using 64Ni target for a preclinical study.METHODS:
67Cu was produced from an electrodeposited 64Ni target via the 64Ni(α, p)67Cu-reaction with a 36â¯MeV alpha beam at 15â¯eµA (electrical microampere) conducted for 7â¯h. The chemical separation process of 67Cu from the 64Ni target was performed following by our routine procedure of 64Cu production using cation exchange resin, AG50W-X8, with minor modification. The target and its holder were redesigned in the preparation.RESULTS:
The 67Cu product was obtained with a yield of 55⯱â¯10â¯MBq at the end of bombardment (EOB), and the yield was 527⯱â¯96â¯kBq/µAh at the EOB. The copper impurity in the product was low (0.71⯱â¯0.21⯵g) and the product was suitable for a preclinical study.CONCLUSIONS:
We produced 67Cu with sufficient activity and quality for a preclinical study using a 64Ni-target. This production method also showed advantages as a routine method, i.e., shorten the processing time, reducing the radiation exposure and ready target recycling, when compared with that of a conventional Zn-target used for 67Cu production.Palabras clave
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Base de datos:
MEDLINE
Asunto principal:
Radioquímica
/
Radioisótopos de Cobre
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Isótopos
/
Níquel
Idioma:
En
Revista:
Nucl Med Biol
Asunto de la revista:
BIOLOGIA
/
MEDICINA NUCLEAR
Año:
2018
Tipo del documento:
Article