Modulation of ß-glucocerebrosidase increases &#945;-synuclein secretion and exosome release in mouse models of Parkinson's disease.

Papadopoulos, Vassilis E; Nikolopoulou, Georgia; Antoniadou, Ivi; Karachaliou, Antonia; Arianoglou, Giovanna; Emmanouilidou, Evangelia; Sardi, S Pablo; Stefanis, Leonidas; Vekrellis, Kostas

Modulation of ß-glucocerebrosidase increases α-synuclein secretion and exosome release in mouse models of Parkinson's disease.

Papadopoulos, Vassilis E; Nikolopoulou, Georgia; Antoniadou, Ivi; Karachaliou, Antonia; Arianoglou, Giovanna; Emmanouilidou, Evangelia; Sardi, S Pablo; Stefanis, Leonidas; Vekrellis, Kostas.

Afiliación

Papadopoulos VE; Center of Basic Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.
Nikolopoulou G; Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Antoniadou I; Center of Basic Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.
Karachaliou A; Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Arianoglou G; Center of Basic Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.
Emmanouilidou E; Department of Life Sciences, School of Sciences, European University Cyprus, Nicosia 1516, Cyprus.
Sardi SP; Center of Basic Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.
Stefanis L; School of Science, Faculty of Biology, National and Kapodistrian University of Athens, 15772 Athens, Greece.
Vekrellis K; Center of Basic Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.

Hum Mol Genet ; 27(10): 1696-1710, 2018 05 15.

Article en En | MEDLINE | ID: mdl-29547959

Asunto(s)

Exosomas/genética; Glucosilceramidasa/genética; Enfermedad de Parkinson/genética; alfa-Sinucleína/genética; Animales; Encéfalo/metabolismo; Encéfalo/fisiopatología; Modelos Animales de Enfermedad; Exosomas/metabolismo; Glucosilceramidasa/metabolismo; Humanos; Inositol/administración & dosificación; Inositol/análogos & derivados; Lisosomas/genética; Lisosomas/metabolismo; Ratones; Mutación; Enfermedad de Parkinson/fisiopatología

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Alfa-Sinucleína / Exosomas / Glucosilceramidasa Límite: Animals / Humans Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2018 Tipo del documento: Article País de afiliación: Grecia

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