IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.

Karki, Rajendra; Lee, Ein; Place, David; Samir, Parimal; Mavuluri, Jayadev; Sharma, Bhesh Raj; Balakrishnan, Arjun; Malireddi, R K Subbarao; Geiger, Rechel; Zhu, Qifan; Neale, Geoffrey; Kanneganti, Thirumala-Devi

Karki, Rajendra; Lee, Ein; Place, David; Samir, Parimal; Mavuluri, Jayadev; Sharma, Bhesh Raj; Balakrishnan, Arjun; Malireddi, R K Subbarao; Geiger, Rechel; Zhu, Qifan; Neale, Geoffrey; Kanneganti, Thirumala-Devi.

Afiliación

Karki R; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Lee E; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Place D; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Samir P; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Mavuluri J; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Sharma BR; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Balakrishnan A; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Malireddi RKS; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Geiger R; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Zhu Q; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Neale G; Hartwell Center for Bioinformatics & Biotechnology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kanneganti TD; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: thirumala-devi.kanneganti@stjude.org.

Cell ; 173(4): 920-933.e13, 2018 05 03.

Article en En | MEDLINE | ID: mdl-29576451

Asunto(s)

Proteínas Reguladoras de la Apoptosis/metabolismo; Proteínas de Unión al Calcio/metabolismo; Inflamasomas/metabolismo; Factores Reguladores del Interferón/metabolismo; Proteína Inhibidora de la Apoptosis Neuronal/metabolismo; Animales; Proteínas Reguladoras de la Apoptosis/genética; Proteínas de Unión al Calcio/genética; Células Cultivadas; Citocinas/metabolismo; Ensayo de Cambio de Movilidad Electroforética; Flagelina/metabolismo; Factores Reguladores del Interferón/antagonistas & inhibidores; Factores Reguladores del Interferón/genética; Macrófagos/citología; Macrófagos/metabolismo; Macrófagos/microbiología; Ratones; Proteína con Dominio Pirina 3 de la Familia NLR/genética; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Proteína Inhibidora de la Apoptosis Neuronal/genética; Regiones Promotoras Genéticas; Unión Proteica; Pseudomonas aeruginosa/patogenicidad; Piroptosis; Interferencia de ARN; ARN Interferente Pequeño/metabolismo; Salmonella typhimurium/patogenicidad; Transcripción Genética

Palabras clave

Burkholderia; ICSBP; IRF8; NAIP; NLR; NLRC4; PU.1; Salmonella; caspase-1; inflammasome

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Proteínas de Unión al Calcio / Factores Reguladores del Interferón / Proteínas Reguladoras de la Apoptosis / Proteína Inhibidora de la Apoptosis Neuronal / Inflamasomas Límite: Animals Idioma: En Revista: Cell Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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