Thrombotic Microangiopathy-Like Hemolysis in Vitamin B12 Deficiency-Related Macrocytic Anemia.
Clin Lab
; 64(4): 639-643, 2018 Apr 01.
Article
en En
| MEDLINE
| ID: mdl-29739088
ABSTRACT
BACKGROUND:
Hemolytic features in patients with pernicious anemia have not been emphasized.METHODS:
Seven Japanese patients at 60 - 88 years of age with vitamin B12 deficiency-related hemolytic anemia were assessed.RESULTS:
Serum vitamin B12 levels in these cases were 46 - 89 pg/mL (normal reference range 233 - 914 pg/mL). Clinically, the patients presented with thrombotic microangiopathy (TMA)-like hemolytic features (including macrocytic anemia, schistocytes on blood smears, high serum lactate dehydrogenase, hyperbilirubinemia, and low serum haptoglobin). Six cases had type A gastritis (assessed by esophagogastroduodenoscopy with hypergastrinemia) with additional laboratory data of high plasma homocysteine levels and anti-intrinsic factor/anti-parietal cell antibodies. One case was in post-gastrectomy condition. Following treatment with vitamin B12, anemia resolved within 4 weeks in five of the seven cases except for two cases of delayed response.CONCLUSIONS:
In elderly patients exhibiting hemolytic features in association with macrocytic anemia, vitamin B12 deficiency should be considered in the differential diagnosis.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Deficiencia de Vitamina B 12
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Microangiopatías Trombóticas
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Hemólisis
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Anemia Macrocítica
Tipo de estudio:
Diagnostic_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Lab
Asunto de la revista:
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Año:
2018
Tipo del documento:
Article