Role of hormonal and inflammatory alterations in obesity-related reproductive dysfunction at the level of the hypothalamic-pituitary-ovarian axis.
Reprod Biol Endocrinol
; 16(1): 45, 2018 May 09.
Article
en En
| MEDLINE
| ID: mdl-29743077
ABSTRACT
BACKGROUND:
Besides being a risk factor for multiple metabolic disorders, obesity could affect female reproduction. While increased adiposity is associated with hormonal changes that could disrupt the function of the hypothalamus and the pituitary, compelling data suggest that obesity-related hormonal and inflammatory changes could directly impact ovarian function.OBJECTIVE:
To review the available data related to the mechanisms by which obesity, and its associated hormonal and inflammatory changes, could affect the female reproductive function with a focus on the hypothalamic-pituitary-ovarian (HPO) axis.METHODS:
PubMed database search for publications in English language until October 2017 pertaining to obesity and female reproductive function was performed.RESULTS:
The obesity-related changes in hormone levels, in particular leptin, adiponectin, ghrelin, neuropeptide Y and agouti-related protein, are associated with reproductive dysfunction at both the hypothalamic-pituitary and the ovarian levels. The pro-inflammatory molecules advanced glycation end products (AGEs) and monocyte chemotactic protein-1 (MCP-1) are emerging as relatively new players in the pathophysiology of obesity-related ovarian dysfunction.CONCLUSION:
There is an intricate crosstalk between the adipose tissue and the inflammatory system with the HPO axis function. Understanding the mechanisms behind this crosstalk could lead to potential therapies for the common obesity-related reproductive dysfunction.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Ovario
/
Enfermedades del Sistema Endocrino
/
Sistema Hipotálamo-Hipofisario
/
Infertilidad Femenina
/
Inflamación
/
Obesidad
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Reprod Biol Endocrinol
Asunto de la revista:
ENDOCRINOLOGIA
/
MEDICINA REPRODUTIVA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos