[Correlation study between the levels of serum MCP-1,SAA and cognitive function in patients with COPD-OSAHS].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
; 32(7): 485-488, 2018 Apr.
Article
en Zh
| MEDLINE
| ID: mdl-29798074
ABSTRACT
Objective:
To study the correlation among the serum monocyte chemoattractant protein-1 (MCP-1),serum amyloid A(SAA) and the level of cognitive function in patients with chronic obstructive pulmonary disease and obstructive sleep apnea hypopnea syndrome overlap syndrome(OS).Method:
Sixty patients with OS were in the experimental group, and 33 patients with COPD were in control group. The serum levels of MCP-1 and SAA were measured, and the correlation among MCP-1, SAA and cognitive function was observed by the Montreal scale.Result:
â The serum levels of MCP-1 and SAA in OS group were (159.85±21.38)ng/L and (122.64±42.49)ng/L respectively,which in control group were (135.02±15.31)ng/L and (71.37±10.16)ng/L respectively.There were the was statistically significant difference between the two groups(P<0.05). â¡Montreal scale score and its sub items in OS group were lower than the control group.The difference was statistically significant (P<0.05).â¢There was significant negative correlation between Montreal scale and the serum levels of MCP-1(r=-0.654,P<0.05) and SAA (r=-0.617,P<0.05) in OS group.Conclusion:
Patients in the OS group had obvious cognitive impairment compared with the ones in control group, which suggested that OSAHS might be an independent risk factor for cognitive impairment. The cognitive function of OS patients was negatively related to MCP-1 and SAA, which suggested that MCP-1 and SAA played a role in the occurrence of cognitive impairment in OS patients.Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Proteína Amiloide A Sérica
/
Quimiocina CCL2
/
Apnea Obstructiva del Sueño
/
Enfermedad Pulmonar Obstructiva Crónica
/
Disfunción Cognitiva
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
Zh
Revista:
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
Año:
2018
Tipo del documento:
Article
País de afiliación:
China