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Sonochemical synthesis of cellulose/hydroxyapatite nanocomposites and their application in protein adsorption.
Fu, Lian-Hua; Qi, Chao; Liu, Yan-Jun; Cao, Wen-Tao; Ma, Ming-Guo.
Afiliación
  • Fu LH; Beijing Key Laboratory of Lignocellulosic Chemistry, College of Materials Science and Technology, Beijing Forestry University, Beijing, 100083, PR China.
  • Qi C; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, China.
  • Liu YJ; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.
  • Cao WT; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Laboratory of Evolutionary Theranostics, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, 518060, China.
  • Ma MG; Beijing Key Laboratory of Lignocellulosic Chemistry, College of Materials Science and Technology, Beijing Forestry University, Beijing, 100083, PR China.
Sci Rep ; 8(1): 8292, 2018 05 29.
Article en En | MEDLINE | ID: mdl-29844448
ABSTRACT
Hydroxyapatite (HA) is the main mineral constituent in the hard tissue of vertebrate, which is recognized as an important biomedical material owing to its excellent bioactivity and biocompatibility. Herein, we report a facile and green sonochemical route for the rapid synthesis of cellulose/HA nanocomposites in NaOH/urea aqueous solution. The in vitro behavior of the cellulose/HA nanocomposites was studied to evaluate the biological response of the nanocomposites following immersion in simulated body fluid for various periods (maximum of 28 days). The HA crystals formed on the surface of the nanocomposites were carbonate-containing apatite, which is similar to the naturally occurring calcium phosphate materials. The HA nanosheets (assembly of nanorods) were mineralized on the surface of the nanocomposites, and maximum mass of the nanocomposites was reached 1.82 times of initial mass after 28 days of soaking. Moreover, the as-prepared cellulose/HA nanocomposites have good cytocompatibility, and show a relatively high protein adsorption ability using hemoglobin as a model protein. These results indicate that the as-prepared cellulose/HA nanocomposites are promising for applications in various biomedical fields such as tissue engineering and protein/drug delivery.
Asunto(s)

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ultrasonido / Materiales Biocompatibles / Proteínas / Celulosa / Durapatita / Nanocompuestos Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article

Texto completo: 1 Base de datos: MEDLINE Asunto principal: Ultrasonido / Materiales Biocompatibles / Proteínas / Celulosa / Durapatita / Nanocompuestos Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article