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Biocompatible silk/calcium silicate/sodium alginate composite scaffolds for bone tissue engineering.
Zheng, Ao; Cao, Lingyan; Liu, Yang; Wu, Jiannan; Zeng, Deliang; Hu, Longwei; Zhang, Xiangkai; Jiang, Xinquan.
Afiliación
  • Zheng A; Department of Prosthodontics, Oral Bioengineering and Regenerative Medicine Lab, Shanghai Key Laboratory of Stomatology, Ninth People's Hospital Affiliated to Shanghai JiaoTong University, School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China; Oral Bioengineering Lab, Shanghai Research Insti
  • Cao L; Department of Prosthodontics, Oral Bioengineering and Regenerative Medicine Lab, Shanghai Key Laboratory of Stomatology, Ninth People's Hospital Affiliated to Shanghai JiaoTong University, School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China; Oral Bioengineering Lab, Shanghai Research Insti
  • Liu Y; The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
  • Wu J; Department of Prosthodontics, Oral Bioengineering and Regenerative Medicine Lab, Shanghai Key Laboratory of Stomatology, Ninth People's Hospital Affiliated to Shanghai JiaoTong University, School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China; Oral Bioengineering Lab, Shanghai Research Insti
  • Zeng D; Department of Prosthodontics, Oral Bioengineering and Regenerative Medicine Lab, Shanghai Key Laboratory of Stomatology, Ninth People's Hospital Affiliated to Shanghai JiaoTong University, School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China; Oral Bioengineering Lab, Shanghai Research Insti
  • Hu L; Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai 200011, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Cent
  • Zhang X; Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai 200011, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Cent
  • Jiang X; Department of Prosthodontics, Oral Bioengineering and Regenerative Medicine Lab, Shanghai Key Laboratory of Stomatology, Ninth People's Hospital Affiliated to Shanghai JiaoTong University, School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China; Oral Bioengineering Lab, Shanghai Research Insti
Carbohydr Polym ; 199: 244-255, 2018 Nov 01.
Article en En | MEDLINE | ID: mdl-30143127
ABSTRACT
Scaffolds are crucial for bone tissue engineering since their compositions and properties could significantly affect the seeded cells' behavior. In this study, we developed an interpenetrating network hydrogel by utilizing Ca2+ from calcium silicate (CS) to simultaneously crosslink silk fibroin (SF) and sodium alginate (SA). Afterwards, the hydrogels were lyophilized to obtain scaffolds and systematically evaluated by physical characterizations, in vitro cytocompatibility and alkaline phosphatase (ALP) assay. We found that CS inside the porous structure of SF/CS/SA scaffolds could remarkably enhance hydrophilicity, degradation, compression resistance, bioactivity and pH of SF/CS/SA scaffolds. Scaffolds with CS concentrations of 25% and 12% (25/CS and 12/CS) could dominantly stimulate proliferation of bone marrow stromal cells (BMSCs). Besides, BMSCs cultured with 25/CS and 12/CS scaffolds showed high ALP activity, respectively. Consequently, this study suggested SF/CS/SA scaffolds possess potential in non-loading bone tissue engineering application.
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Silicatos / Compuestos de Calcio / Alginatos / Andamios del Tejido / Células Madre Mesenquimatosas / Fibroínas Límite: Animals Idioma: En Revista: Carbohydr Polym Año: 2018 Tipo del documento: Article
Texto completo
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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Silicatos / Compuestos de Calcio / Alginatos / Andamios del Tejido / Células Madre Mesenquimatosas / Fibroínas Límite: Animals Idioma: En Revista: Carbohydr Polym Año: 2018 Tipo del documento: Article