Innate and adaptive immunity in necrotizing enterocolitis.
Semin Fetal Neonatal Med
; 23(6): 394-399, 2018 12.
Article
en En
| MEDLINE
| ID: mdl-30146477
ABSTRACT
Necrotizing enterocolitis (NEC) is the most frequent and devastating gastrointestinal disease of premature infants. Although the precise mechanisms are not fully understood, NEC is thought to develop following a combination of prematurity, formula feeding, and adverse microbial colonization. Within the last decade, studies increasingly support an important role of a heightened mucosal immune response initiating a pro-inflammatory signaling cascade, which can lead to the disruption of the intestinal epithelium and translocation of pathogenic species. In this review, we first describe the cellular composition of the intestinal epithelium and its critical role in maintaining epithelial integrity. We then discuss cell signaling during NEC, specifically, toll-like receptors and nucleotide oligomerization domain-like receptors. We further review cytokines and cellular components that characterize the innate and adaptive immune systems and how they interact to support or modulate NEC development.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Enterocolitis Necrotizante
/
Inmunidad Adaptativa
/
Inmunidad Innata
Límite:
Humans
/
Newborn
Idioma:
En
Revista:
Semin Fetal Neonatal Med
Asunto de la revista:
PEDIATRIA
/
PERINATOLOGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos