Proteomic analysis of human T cell-derived exosomes reveals differential RAS/MAPK signaling.
Eur J Immunol
; 48(11): 1915-1917, 2018 11.
Article
en En
| MEDLINE
| ID: mdl-30207595
ABSTRACT
Exosomes are cell-derived vesicles that have been implicated in the pathogenesis of many inflammatory diseases. More specifically, it has been shown that T cell-derived exosomes can induce immunological responses; however, little is known about the mechanism and the molecular content of these vesicles. Here, we used a proteomic approach to characterize human T cell-derived exosomes. We found that specific proteins of the RAS signaling pathway were enriched in exosomes derived from activated T cells, and that these vesicles induced ERK phosphorylation in recipient immune cells. Our findings support a mechanistic role of exosomes in cellular activation, and further studies should consider exosomes as a biomarker for inflammatory diseases.
Palabras clave
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Linfocitos T
/
Transducción de Señal
/
Proteínas ras
/
Sistema de Señalización de MAP Quinasas
/
Exosomas
Límite:
Humans
Idioma:
En
Revista:
Eur J Immunol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Estados Unidos