Utility of an "Allosteric Site-Impaired" M<sub>2</sub> Muscarinic Acetylcholine Receptor as a Novel Construct for Validating Mechanisms of Action of Synthetic and Putative Endogenous Allosteric Modulators.

Moo, Ee Von; Sexton, Patrick M; Christopoulos, Arthur; Valant, Celine

Utility of an "Allosteric Site-Impaired" M₂ Muscarinic Acetylcholine Receptor as a Novel Construct for Validating Mechanisms of Action of Synthetic and Putative Endogenous Allosteric Modulators.

Moo, Ee Von; Sexton, Patrick M; Christopoulos, Arthur; Valant, Celine.

Afiliación

Moo EV; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Sexton PM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Christopoulos A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia arthur.christopoulos@monash.edu celine.valant@monash.edu.
Valant C; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia arthur.christopoulos@monash.edu celine.valant@monash.edu.

Mol Pharmacol ; 94(5): 1298-1309, 2018 11.

Article en En | MEDLINE | ID: mdl-30213802

Asunto(s)

Colinérgicos/farmacología; Receptor Muscarínico M2/efectos de los fármacos; Sitio Alostérico; Animales; Sitios de Unión; Células CHO; Cricetulus; Cinética; Ligandos; Mutación; N-Metilescopolamina/farmacología; Receptor Muscarínico M2/genética; Receptor Muscarínico M2/metabolismo; Reproducibilidad de los Resultados

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Texto completo: 1 Base de datos: MEDLINE Asunto principal: Colinérgicos / Receptor Muscarínico M2 Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Mol Pharmacol Año: 2018 Tipo del documento: Article País de afiliación: Australia

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